The Lukesh lab uses synthetic organic chemistry in an effort to generate novel redox-active molecules with interesting biological properties. With a broad interest in molecular design and its application to biology and medicine, we are actively pursuing the following areas of research:

Chemical Biology: The design and synthesis of new investigative tools (small molecule donors and reaction-based sensors) for probing the chemical biology of reactive sulfur and selenium species within a biological setting.

Medicinal Chemistry: The design and synthesis of novel organoselenium molecules with useful redox properties and therapeutic applications.

Synthetic Methodology Development: New synthetic methods involving organoselenium reagents and catalysts for the construction of privileged heterocyclic scaffolds via key C–C bond forming reactions.

Students participating in this research are exposed to a wide variety of topics and techniques at the ever-widening interface of chemistry and biology.

We are grateful for financial support from the National Science Foundation under Grant No. 2143826.