The Lukesh lab uses synthetic organic chemistry in an effort to generate novel redox-active molecules with interesting biological properties. With a broad interest in molecular design and its application to biology and medicine, we are actively pursuing the following areas of research:
Medicinal Chemistry: Construction of novel selenium-containing scaffolds with useful redox properties and therapeutic applications.
Chemical Biology: Elucidating the roles of hydrogen sulfide—an important signaling molecule expressed in mammalian systems—through molecular design and the development of novel reaction-based probes and donor scaffolds.
Synthetic Methodology Development: New methods involving electrophilic selenium catalysis for accessing privileged heterocyclic scaffolds via key C–C bond forming reactions.
Students participating in this research are exposed to a wide variety of topics and techniques at the ever-widening interface of chemistry and biology.